REVIEW

O Que Todo Neurocirurgião Deve Saber Sobre Disreflexia Autonômica em Lesado Medular

What Every Neurosurgeon Should Know About Autonomic Dysreflexia in a Spinal Cord Injury

  • Carlos Umberto Pereira (1)    Carlos Umberto Pereira (1)
  • Débora Moura da Paixão Oliveira (2)    Débora Moura da Paixão Oliveira (2)
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Resumo

Introdução: Disreflexia autonômica medular (DAM) tem sido comum em pacientes vítimas de traumatismo raquimedular acima de T6. É considerada uma emergência médica. Um diagnóstico e tratamento adequado podem prevenir danos irreversíveis para os pacientes. Metodologia: Artigo de revisão de literatura utilizando as bases de dados LILACS, Ebsco, Scielo, PubMed e Cochrane usando os seguintes termos “autonomic dysreflexia”, “autonomic hyperreflexia”, “autonomic dysfunction” e “spinal cord cervical injury”. Resultados: Foram selecionados 37 artigos desde 1952 a 2016, pela sua relevância no tema abordado. Conclusão: Existem alguns pontos sobre a DAM que devem ser revistos. Primeiro, a deficiência de conhecimento no seu diagnóstico entre os profissionais de saúde que trabalham em emergência; segundo, as complicações que podem ser fatais para o paciente.

Palavras-chave

Sistema nervoso autônomo; Lesão medular cervical; Disfunção autonômica

Abstract

Introduction: Spinal cord autonomic dysreflexia (AMD) has been common in patients with spinal cord injury above T6. It is considered a medical emergency. Proper diagnosis and treatment can prevent irreversible damage to patients. Methodology: literature review article using the LILACS, Ebsco, Scielo, PubMed and Cochrane databases using the following search terms ‘autonomic dysreflexia’, ‘autonomic hyperreflexia’, ‘autonomic dysfunction’ and ‘spinal cord cervical injury’. Results: A total of 37 articles was selected from 1952 to 2016, due to their relevance to the topic addressed. Conclusion: There are some reasons to review the AMD. Firstly, the lack of knowledge in its diagnosis among health professionals working in emergency, and in second, complications that can be fatal for the patient.

Keywords

Autonomic nervous system; Spinal cord cervical injury; Autonomic dysfunction

References

1. Setton ARF, Pereira CU, Santos JL. Hiperreflexia autonômica simpática. Revisão da Literatura. J Bras Neurocirur. 1995;6(2):49-54.

2. Blackmer J. Rehabilitation medicine: 1. Autonomic dysreflexia. CMAJ. 2003;169(9):931-5. PMid:14581313.

3. Brown R, Burton A, Macefield VG. Input-output relationships of a somatosympathetic reflex in human spinal injury. Clin Auton Res. 2009;19(4):213-20. http://dx.doi.org/10.1007/s10286-009-0010-9. PMid:19377855.

4. Bycroft J, Shergill IS, Chung EA, Arya N, Shah PJ. Autonomic dysreflexia: a medical emergency. Postgrad Med J. 2005;81(954):232-5. http://dx.doi.org/10.1136/pgmj.2004.024463. PMid:15811886.

5. Eker A, Yigitoglu PH, Ipekdal I, Tosun A. Acute onset of intracerebral hemorrhage due to autonomic dysreflexia. J Korean Neurosurg Soc. 2014;55(5):277-9. http://dx.doi.org/10.3340/jkns.2014.55.5.277. PMid:25132935.

6. Erickson RP. Autonomic hyperreflexia: pathophysiology and medical management. Arch Phys Med Rehabil. 1980;61(10):431-40. PMid:6107074.

7. Karlsson AK. Autonomic dysreflexia. Spinal Cord. 1999;37(6):383-91. http://dx.doi.org/10.1038/sj.sc.3100867. PMid:10432257.

8. Roque V, Cunha I, Rocha A, Andrade MJ. Disfunções autonómicas após lesão medular. Rev Soc Portuguesa Med Fis Reabilit. 2013;21(2):43-51.

9. Teasell RW, Arnold AP, Krassioukov AV, Delaney GA. Cardiovascular  consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury. Arch Phys Med Rehabil. 2000;81(4):506-16.  http://dx.doi.org/10.1053/mr.2000.3848. PMid:10768544.

10. Dolinak D, Balraj E. Autonomic dysreflexia and sudden death in people with traumatic spinal cord injury. Am J Forensic Med Pathol. 2007;28(2):95-8. http://dx.doi.org/10.1097/PAF.0b013e3180600f99. PMid:17525555.

11. Toledo-Perdomo K, Viña-Cabrera Y, Martín-Urcuyo B, Morales-Umpiérrez A. Hypertensive crisis in a patient with a medullary lesion. Nefrologia. 2015;35(3):329-31. http://dx.doi.org/10.1016/j.nefro.2015.05.001. PMid:26299176.

12. Helkowski WM, Ditunno JF Jr, Boninger M. Autonomic dysreflexia: incidence in persons with neurologically complete and incomplete tetraplegia. J Spinal Cord Med. 2003;26(3):244-7. http://dx.doi.org/10.1080/10790268.2003.11753691. PMid:14997966.

13. Krassioukov A, Warburton DE, Teasell R, Eng JJ, SPINAL CORD INJURY REHABILITATION EVIDENCE RESEARCH TEAM. A systemic review of the management of autonomic dysreflexia after spinal cord injury. Arch Phys Med Rehabil. 2009;90(4):682-95. http://dx.doi.org/10.1016/j.apmr.2008.10.017. PMid:19345787.

14. Weaver LC. What causes autonomic dysreflexia after spinal cord injury? Clin Auton Res. 2002;12(6):424-6. http://dx.doi.org/10.1007/s10286-002-0076-0. PMid:12607521.

15. Bors E, French JD. Management of paroxysmal hypertension following injuries to cervical and upper thoracic segments of the spinal cord. AMA Arch Surg. 1952;64(6):803-12. http://dx.doi.org/10.1001/archsurg.1952.01260010823012. PMid:14923104.

16. Trop CS, Bennett CJ. Autonomic dysreflexia and its urological implications: a review. J Urol. 1991;146(6):1461-9. http://dx.doi.org/10.1001/10.1016/s0022-5347(17)38140-5. PMID: 1942319.

17. Lindan R, Joiner E, Freehafer AA, Hazel C. Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury. Paraplegia. 1980;18(5):285-92. PMid:7443280.

18. Dunn KL. Identification and management of autonomic dysreflexia in the  emergency department. Top Emerg Med. 2004;26(3):254-9.

19. Richa FC. Autonomic hyperreflexia after spinal cord injury. J Spine. 2014;4(1):196.

20. Petit JS, Delahaye JM, Malinovsky JM. Perioperative management of traumatic spinal cord injured patients after the acute phase. Ann Fr Anesth Reanim. 2008;27(5):416-25. http://dx.doi.org/10.1016/j.annfar.2008.03.005. PMid:18436419.

21. Burns AS, Jackson AB. Ginecologic and reproductive issues in women with spinal cord injury. Phys Med Rehabil Clin N Am. 2001;12(1):183-99. http://dx.doi.org/10.1016/S1047-9651(18)30090-1. PMid:11853036.

22. Dincer U. Autonomic dysfunction and their treatment in spinal cord injury. Turk J Phys Med Rehabil. 2010;56(Suppl 2):93-8.

23. Weaver LC, Marsh DR, Gris D, Brown A, Dekaban GA. Autonomic dysreflexia after spinal cord injury: central mechanisms and strategies for prevention. Prog Brain Res. 2006;152:245-63. http://dx.doi.org/10.1016/S0079-6123(05)52016-8. PMid:16198705.

24. Curt A, Nitsche B, Rodic B, Schurch B, Dietz V. Assessment of autonomic dysreflexia in patients with spinal cord injury. J Neurol Neurosurg Psychiatry. 1997;62(5):473-7. http://dx.doi.org/10.1136/jnnp.62.5.473. PMid:9153603.

25. Linsenmeyer TA, Campagnolo DI, Chou IH. Silent autonomic dysreflexia during voiding in men with spinal cord injuries. J Urol. 1996;155(2):519-22. http://dx.doi.org/10.1016/S0022-5347(01)66438-3. PMid:8558650.

26. Eltorai IM, Wong DH, Lacerna M, Comarr AE, Montroy R. Surgical aspects of autonomic dysreflexia. J Spinal Cord Med. 1997;20(3):361-4. PMid:9261784.

27. Vallès M, Benito J, Portell E, Vidal J. Cerebral hemorrhage due to autonomic dysreflexia in a spinal cord injury patient. Spinal Cord. 2005;43(12):738-40. http://dx.doi.org/10.1038/sj.sc.3101780. PMid:16010281.

28. Lee BY, Karmakar MG, Herz BL, Sturgill RA. Autonomic dysreflexia revisited. J Spinal Cord Med. 1995;18(2):75-87. PMid:7640977.

29. Wu KP, Lai PL, Lee LF, Hsu CC. Autonomic dysreflexia triggered by an unstable lumbar spine in a quadriplegic patient. Chang Gung Med J. 2005;28(7):508-11. PMid:16231536.

30. Leão P, Figueiredo P. Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report. Patient Saf Surg. 2016;10(1):10. http://dx.doi.org/10.1186/s13037-016-0098-5. PMid:26985238.

31. Vatansever N. A nursing diagnosis: autonomic dysreflexia. Inter J Caring Sciences. 2015;8(3):837-42.

32. Comarr AE, Eltorai I. Autonomic dysreflexia/hyperreflexia. J Spinal Cord Med. 1997;20(3):345-54. PMid:9261782.

33. Gilgoff IS, Ward SLD, Hohn AR. Cardiac pacemaker in high spinal cord injury. Arch Phys Med Reabil. 1991;72(8):601-3.

34. Phillips AA, Zheng MMZ, Elliott SL, Krassioukov AV. Prazosin: a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury? Neural Regen Res. 2015;10(4):557-8. http://dx.doi.org/10.4103/1673-5374.155422. PMid:26170812.

35. Phillips AA, Elliott SL, Zheng MM, Krassioukov AV. Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury. J Neurotrauma. 2015;32(6):392-6. http://dx.doi.org/10.1089/neu2014.3590. PMid:25093677.

36. Feyzi F, Vahedi M, Daneshmandi M, Ebadi A, Sirati M, Amiri H. Relationship of demographic characteristics of nurses with knowledge about autonomic dysreflexia in spinal cord injured veterans. Iranian J Milit Med. 2011;13(2):71-4.

37. Schottler J, Vogel L, Chafetz R, Mulcahey MJ. Patient and caregiver knowledge of autonomic dysreflexia among youth with spinal cord injury. Spinal Cord. 2009;47(9):681-6. http://dx.doi.org/10.1038/sc.2009.12. PMid:19274058.


1MD, PhD, Neurosurgeon, Hospital de Urgências de Sergipe (HUSE), Aracaju, SE, Brazil.

2PhD in Health Sciences, Nurse, Vice-president of the Associação Brasileira de Enfermagem em Neurologia e Neurocirurgia (ABENEURO), Aracaju, SE, Brazil.

 

Received May 31, 2022
Corrected Jul 25, 2022
Accepted Aug 2, 2022

JBNC  Brazilian Journal of Neurosurgery

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