ORIGINAL

Anatomia Microcirúrgica e abordagens ao seio cavernoso

Microsurgical anatomy and approaches to the cavernous sinus: an stereoscopic 3-D study with clinical-radiological correlations

  • Gustavo Rassier Isolan 1,3,4,5
  • Leonardo Vedolin 2
  • Débora Bertholdo 2
  • Leandro Infantini Dini 4
  • Francisco Braga 5
  • Gerson Perondi 5
  • Ápio Cláudio Martins Antunes 3
  • Nilo Mario Monteiro Lopes 1
  • Marco Antônio Stefani 3
  • Paulo Oppitz 3
  • Mariana Werneck 6
  • Rafael Cristovam 7
  • J Bras Neurocirurg 22 (1): 8-44, 2011

Resumo

O seio cavernoso é uma das regiões mais complexas do corpo

humano e pode ser acometido por diversas patologias. Atualmente,

diversos tipos de tratamento podem ser usados para

tratar doenças nesta região, porém o conhecimento anatômico

ainda é fundamental para estabelecer o melhor manejo. Nosso

objetivo é apresentar a anatomia microcirúrgica do seio cavernoso,

as abordagens cirúrgicas (incluindo a abordagem endonasal

endoscópica), a correlação radiológica desta anatomia,

bem como uma série inicial de casos. As fotos são apresentadas

pelo método convencional e anaglífico estereoscópico. São

descritas as estruturas neurovasculares do seio cavernoso bem

como suas relações ósseas e durais, as paredes e os triângulos

da base do crânio relacionados ao seio cavernoso. As abordagens

crânio-órbito zigomática, transpetrosa, zigomática e

endonasal endoscópica são apresentadas, sendo as estruturas

anatômicas identificadas também nos exames de imagem. Casos

ilustrativos ilustram esta anatomia.

Palavras-chave

Seio cavernoso, abordagens cirúrgicas, anatomia, tumor, base do cranio

Abstract

The cavernous sinus is one of the most complex regions of the

human body and can be affected by several diseases. Currently,

several types of treatment can be used in the management of

diseases in this region. The anatomical knowledge is essential

to establish the best management. Our goal is to present the

microsurgical anatomy of the cavernous sinus, its surgical approaches

(including the endoscopic endonasal approach), the

correlation of radiological anatomy, including an initial series

of cases. The anatomic features are presented by the conventional

and stereoscopic anaglyphic method. The neurovascular

structures of the cavernous sinus and its dural and bony relationships,

triangles and the walls of the skull base related to

it are presented with. We discuss the cranio-orbital zygomatic,

transpetrosal, zygomatic and endonasal endoscopic approaches;

MRI studies also show the anatomical structures, including

illustrative cases.

Keywords

cavernous sinus, surgical approaches, anatomy, tumor, skull base

References

1. Abdel-Azziz, Abdel-Aziz KM, Froelich SC, Dagnew E, Jean

W, Breneman JC et al. Large sphenoid wing meningiomas involving

the cavernous sinus: conservative surgical strategies for

better functional outcomes Neurosurgery 2004 ; 54(6):1375-83;

discussion 1383-4.

2. Alfieri A, Jho H. Endoscopic endonasal cavernous sinus surgery:

An anatomic study. Neurosurgery 2001; 48(4):827-36.

3. Al-Mefty O. Surgery of the cranial base. Boston. Kluwer Academic

Publishers, 1989

4. Al-Mefty O. Clinoidal meningiomas. J Neurosurg 1990;73:840-9.

5. Al-Mefty O. Operative atlas of meningeomas. Philadelphia.

Lippincott-Raven, 1998.

6. Al-Mefty O. Supraorbital-Pterional approach to skull base lesions.

Neurosurgery 1987; 21(4):474-7.

7. Al-Mefty O, Smith RR. Surgery of tumors invading the cavernous

sinus. Surg. Neurol 1988; 30:370-81.

8. Al-Mefty O, Kadri PA, Hasan DM, Isolan GR, Pravdenkova S.

Anterior clivectomy: surgical technique and clinical applications.

J Neurosurg. 2008; 109(5):783-93.

9. Bassett DL: A Stereoscopic Atlas of Human Anatomy. Portland,

OR: Sawyer, 1961

10. B eltz N , Taner D. – Anatomical variations of the intracavernous

branches of the internal carotid artery with reference to the

relationship of the internal carotid artery and sixth cranial nerve:

a microsurgical study. Acta Anatomica., 1990; 138:238-45.

11. Biglan AW, Sekhar LN, Cheng KP, Wright DC. A protocol for

measuring ophthmologic morbidity and recovery after cranial

base surgery. Skull Base Surg 1994;4:26-31

12. Capo H, Kupersmith MJ, Berenstein A, Choi IS, Diamond GA:

The clinical importance of the inferolateral trunk of the internal

carotid artery. Neurosurgery 1991;28:733-7.

13. Carvounis PE, Katz B. Gamma knife radiosurgery in neuro-ophthalmology.

Curr Opin Ophthalmol 2003;14:317-24.

14. Cavallo LM, Cappabianca P, Galzio R, Iaconetta G, de Divitiis

E, Tschabitscher M: Endoscopic transnasal approach to the cavernous

sinus versus transcranial route:anatomic study. Neurosurgery

2005; 56 (Suppl 2):379–89.

15. Ceylan S, Koc K, Anik I. Endoscopic endonasal transsphenoidal

approach for pituitary adenomas invading the cavernous sinus. J

Neurosurg. 2010 ;112(1):99-107

16. Cusimano MD, Sekhar LN, Sen CN, Pomonis S, Wright DC,

Biglan AW, et al. The results of surgery for benign tumors of the

cavernous sinus. Neurosurgery 1995;37:1-9.

17. Day JD. Microsurgical dissection of the cranial base. Churchill

Livingstone, 1996.

18. Day DJ, Giannotta SL, Fukushima T: Extradural temporopolar

approach to lesions of the upper basilar artery and infrachiasmatic

area. J Neurosurg 1994; 81:230-5.

19. Campero A, Campero AA, Martins C, Yasuda A, Rhoton Jr AL.

Surgical anatomy of the dural walls of the cavernous sinus. J

Clin Neurosci. 2010 Jun;17(6):746-50.

20. DeMonte F, Smith HK, Al-Mefty O. Outcome of aggressive

removal of cavernous sinus meningeomas. J Neurosurg 1994;

81:245-51.

21. de Oliveira, Tedeschi H, Siqueira MG, Peace DA. The pretemporal

approach to the interpeduncular and petroclival regions.

Acta Neurochir (Wien) 1995; 136:204-11.

22. Destrieux C, Velut S, Kakou MK, Lefrancq T, Arbeille B, Santini

J. A new concept in Dorello’s canal microanatomy: the petroclival

venous confluence. J Neurosurg 1997; 87:67-72.

23. Dolenc V. Direct microsurgical repair of intracavernous vascular

lesions. J Neurosurg 1983; 58:824-31.

24. Dolenc VV. A combined epi- and subdural direct approach to carotid-

ophthalmic artery aneurysms. J Neurosurg 1985; 62:667-72.

25. Dolenc VV, Skrap M, Sustersic J, Skrbec M, Morina A: A transcavernous-

transsellar approach to the basilar tip aneurysms. Br J

Neurosurg 1987; 1:251-9.

26. Dolenc VV. Anatomy and surgery of the cavernous Sinus.

Springer Verlag, Wien, 1989.

27. Dolenc VV. Surgery of vascular lesions of the cavernous sinus.

Clin Neurosurg 1990; 36:240-55.

62. Lee Jy, Niranjan A, McInerney J, Kondziolka D, Flickinger JC,

Lunsford LD. Stereotactic radiosurgery providing long-term

tumor control of cavernous sinus meningeomas. J Neurosurg

2002; 97(1):65-72.

63. Linskey ME, Davis SA, Ratanatharathorn V . Relative roles of

microsurgery and stereotactic radiosurgery for the treatment of

patients with cranial meningiomas: a single-surgeon 4-year integrated

experience with both modalities. J Neurosurg. 2005 ;102

( Suppl) :59-70.

64. Lunsford LD. Contemporary management of meningiomas: radiation

therapy as an adjuvant and radiosurgery as an alternative

to surgical removal? J Neurosurg 1994;80:187-90.

65. Mariniello G. Microsurgical anatomy of sympathetic fibres running

inside the cavernous sinus. J Neurosurg Sci 1994;38:1-10.

66. Mariniello G, Annecchiarico H, Sardo L, Buonamassa S, de

Divitiis E.. Connections of sympathetic fibres inside the cavernous

sinus: a microanatomical study. Clin Neurol Neurosurg

2000;102:1-5.

67. Marinkovik S, Gibo H, Vucevic R, Petrovic P. Anatomy of the

cavernous sinus region. J Clin Neurosci 2001; 8(Suppl 1): 78-81.

68. Maruyama K, Shin M, Kurita H, Kawahara N, Morita A, Kirino

T. Proposed treatment strategy for cavernous sinus meningeomas:

a prospective study. Neurosurgery 2004; 55(5):1068-75.

69. Meneses MS , Molinari D , Forte M, Rangel P, Neves T,

Pedroso A et al. – Surgical considerations about the anterior

syphon knee of the internal carotid artery. An anatomical study.

Arq Neuropsiquiatr, 1995; 53(1):34-7.

70. Metellus P, Regis J, Muracciole X, Fuentes S, Dufour H, Nanni

I, et al. Evaluation of fractionated radiotherapy and gamma knife

radiosurgery in cavernous sinus meningiomas: treatment strategy.

Neurosurgery 2005;57:873-86; discussion 873-886.

71. Miyazaki Y, Yamamoto I, Shinozuka S, Sato O. Microsurgical

anatomy of the cavernous sinus. Neurol Med Chir (Tokyo) 1994;

34:150-63.

72. Morita A, Coffey RJ, Foote RL, Schiff D, Gorman D.. Risk

of injury to cranial nerves after gamma knife radiosurgery for

skull base meningiomas: experience in 88 patients. J Neurosurg

1999;90:42-9.

73. Mullan S. Treatment of carotid-cavernous fistulas by cavernous

sinus occlusion. J Neurosurg 1979; 50:131-44.

74. Newman SA. The cavernous sinus. Neurosurg Clin North Am

1999;10:731-57.

75. Newmann S. A prospective study of cavernous sinus surgery

for meningiomas and resultantcommon ophthalmic complications

(an american ophthlamological society( thesis). Trans Am

Ophthalmol Soc 2007;105:392-447.

76. Ojemann RG. Skull-base surgery: a perspective. J Neurosurg

1992;76:569-70.

77. Ojemann RG, Thornton AF, Harsh GR. Management of anterior

cranial base and cavernous sinus neoplasms with conservative

surgery alone or in combination with fractionated photon or stereotactic

proton radiotherapy. Clin Neurosurg 1995;42:71-98.

78. Pamir MN, Kiliç T, Bayrakli F, Peker S. Changing treatment

strategy of cavernous sinus meningiomas: experience of a single

institution. Surg Neurol. 2005; 64 Suppl 2:S58-66.

79. Parkinson D. Collateral circulation of cavernous carotid artery:

Anatomy. Can J Surg 1964; 7:251-68.

80. Parkinson D. A surgical approach to the cavernous portion of the

carotid artery: anatomical studies and case report. J Neurosurg

1965; 23:474-83.

81. Parkinson D. Transcavernous repair of carotid cavernous fistula.

J Neurosurg 1969; 26;420-24.

82. Poletti CE, Ojemann RG: Stereo Atlas of Operative Microneurosurgery.

St. Louis: Mosby, 1985

83. Pollock BE, Stafford SL. Results of stereotactic radiosurgery for

patients with imaging defined cavernous sinus meningiomas..

Int J Radiat Oncol Biol Phys 2005;62:1427-31

84. Reisch R, Vutskits L, Patonay L, Fries G – The meningohypofiseal

trunk and its blood supply to different intracranial structures.

An anatomical study. Minim. Invasive Neurosurg 1996;

39(3):78-81.

85. Renn WH , Rhoton Jr AL – Microsurgical anatomy of the sellar

region. J Neurosurg. 1975; 43:288-98.

86. Rhoton Jr AL : The supratentorial cranial space: Microsurgical

anatomy and surgical approaches. Neurosurgery 21[Suppl 1]:

2002; 375-410.

87. Rhoton Jr AL , Inoue T. – Microsurgical approach to the cavernous

sinus. In: Clinical Neurosurgery. Baltimore, The Willian &

Wilkins Company, 1989. P 391-439.

88. Ribas GC, Bento RF, Rodrigues AJ: Anaglyphic three-dimensional

stereoscopic printing: revival of an old method for anatomical

and surgical teaching and reporting. J Neurosurg 2001,

95:1057–66.

89. Roche PH, Regis J, Dufour H, Fournier HD, Delsanti C, Pellet

W, et al. Gamma knife radiosurgery in the management of cavernous

sinus meningiomas. J Neurosurg 2000;93 Suppl 3:68.

90. Saito K, Fukuta K, Takahashi M, Tachibana E, Yoshida J. Management

of the cavernous sinus in en bloc resections of malignant

skull base tumors. Head Neck 1999;21:734-42.

91. Sekhar LN, Moller AR. Operative management of tumors involving

the cavernous sinus. J Neurosurg 1986, 64:879-89.

92. Sekhar LN, Burgess J, Akin O. Anatomical study of the cavernous

sinus emphasizing operative approaches and related vascular

and neural reconstruction. Neurosurgery 1987, 21:806-16.

93. Sekhar LN, Wright DC. Tumors involving the cavernous sinus.

In: Sekhar LN, de Oliveira E (eds). Cranial microsurgery approaches

and techniques. Thieme, 1999.

94. Seone E, Tedeschi H, de Oliveira E, Wen HT, Rhoton Jr AL. The

pretemporal transcavernous approach to the interpeduncular and

prepontine cisterns: Microsurgical anatomy and technique application.

Neurosurgery 2000, 46:891-9.

95. Seone E, Rhoton Jr AL, de Oliveira E . Microsurgical anatomy

of the dural carotid collar (carotid collar) and rings around the

clinoid segment of the internal carotid artery. Neurosurgery

1998, 42:869-86.

96. Sepehrnia A, Samii M, Tatagiba M. Management of intracavernous

tumours: an 11-year experience. Acta Neurochir (Suppl)

1991;53:122-6.

97. Siang, C.C. – Microanatomia do seio cavernoso. São Paulo,

1992. 121p. ( tese de mestrado – Escola Paulista de Medicina).

98. Spektor S, Piontek E, Umansky F. Orbital venous drainage into

the anterior cavernous sinus space: Microanatomic relationships.

Neurosurgery 1997, 40:532-40.

99. Spiegelmann R, Nissim O, Menhel J, Alezra D, Pfeffer MR. Linear

accelerator radiosurgery for meningeomas in and around the

cavernous sinus. Neurosurgery 2002; 51(6):1373-9.

100. Stafford SL, Pollock BE, Leavitt JA, Foote RL, Brown PD, Link

MJ, et al. A study on the radiation tolerance of the optic nerves

and chiasm after stereotactic radiosurgery. Int J Radiat Oncol

Biol Phys 2003;55:1177-81.

101. Taptas JN. The so-called cavernous sinus: a review of the controversy

and its implications for neurosurgeons. Neurosurgery

1982; 11:712-7.

102. Seone E, Tedeschi H, de Oliveira E, Wen HT, Rhoton Jr AL. The

pretemporal transcavernous approach to the interpeduncular and

prepontine cisterns: microsurgical anatomy and technique application.

Neurosurgery 1999; 45:549-92.

103. Sindou M, Pelissou I. Trigeminal neurinomas. A special type

of cavernous sinus tumors. In: Dolenc VV, ed. The Cavernous

Sinus. A Multidisciplinary Approach to Vascular and Tumorous

Lesions. Wien: Springer-Verlag; 1987: p. 355-76.

104. Tedeschi H, de Oliveira EP, Wen HT, Rhoton Jr AL. Perspectives

on the approaches to lesions in and around the cavernous sinus.

Oper Tech Neurosurg 2001; 4:82-107.

105. Tedeschi H, de Oliveira EP, Wen HT, Rhoton Jr AL. Tratamento

cirúrgico das lesões da região do seio cavernoso. Temas atuais

em Neurocirurgia, 2004.

106. Tran-Dinh, H: Cavernous Branches of the internal carotid artery:

anatomy and nomenclature. Neurosurgery 1987; 20(2):205-10.

107. Umansky F, Nathan H. The lateral wall of the cavernous sinus

with special reference to the nerves related to it. J Neurosurgery

1982; 56:228-34.

108. Umansky F, Valarezzo A, Elidan J. The superior wall of the

cavernous sinus: A microanatomical study. J Neurosurg 1994;

81:914-20.

109. Vinuela F, Lylyk P. Endovascular therapy of vascular lesions of

the cavernous sinus. Experience with 129 cases. Pp. 182-197.

In Dolenc VV (ed): The cavernous siuns – A Multidisciplinary

approach to vascular and tumours lesions. Springer Verlag, New

York, 1987.

110. Watanabe A, Nagaseki Y, Ohkubo S, Ohhashi Y, Horikoshi T,

Nishigaya K et al. Anatomical Variations of the ten triangles

around the cavernous sinus. Clin Anat 2003; 16:9-14.

111. Weninger WJ, Muller GB. The parasellar region of human infants:

cavernous sinus topography and surgical approaches. J

Neurosurg 1999;90:484-90.

112. Yilmazlar S, Kocaeli H, Aydiner F, Korfali E: Medial portion of

the cavernous sinus: quantitative analyses of the medial wall.

Clin Anat 2005; 18:416-22.

113. Wen HT, de Oliveira E, Tedeschi H, Andrade FC, Rhoton Jr AL:

The pretemporal approach: surgical anatomy, operative technique,

and rationame. Operative Techniques in Neurosurgery

2001; 4(2):73-81.

114. Yasargil MG: Microneurosurgery: Clinical considerations, Surgery

of the Intracranial Aneurysms and Results. Stuttgart, Georg

Thieme, 1984, Vol II.

115. Yasargil MG, Antic J, Laciga R, Jain K, Hodosh R, Smith R.

Microsurgical pterional approach to aneurysms of the basilar bifurcation.

Surg Neurol 1976; 6:83-91.

116. Yasuda A, Campero A, Martins C, Rhoton AL Jr, Ribas GC.

The medial wall of the cavernous sinus: Microsurgical anatomy.

Neurosurgery 2004; 55:179-90.

117. Yasuda A, Campero A, Martins C, Rhoton AL Jr, de Oliveira E,

Ribas GC. Microsurgical anatomy and approaches to the cavernous

sinus. Neurosurgery 2005; 56:4-27.

118. Z iyal IM, Salas E, Wright DC, Sekhar LN. The petrolingual ligament:

the anatomy and surgical exposure of the posterolateral

landmark of the cavernous sinus. Acta Neurochir 1998;140:201-

4; discussion 204-5.


1. Serviço de Neurologia e Neurocirurgia (Núcleo de Cirurgia da Base do Crânio) do Hospital Moinhos de Vento, Porto Alegre.

2. Serviço de Neuroimagem do Hospital Moinhos de Vento, Porto Alegre

3. Serviço de Neurologia (Unidade de Neurocirurgia) do Hospital de Clínicas de Porto Alegre.

4. Centro de Neurologia e Neurocirurgia Centenário, São Leopoldo, RS

5. Programa de Pós-Graduação em Medicina: Ciências Cirúrgicas da Universidade Federal do Rio Grande do Sul (UFRGS)

6. Acadêmico de Medicina PUC-PR

7. Acadêmico de Medicina UFRGS

 

Recebido em novembro de 2010, aceito em dezembro de 2010

JBNC  Brazilian Journal of Neurosurgery

JBNC
  •   ISSN (print version): 0103-5118
  •   e-ISSN (online version): 2446-6786
iThenticate
Open Access

Contact

Social Media

   

ABNc  Academia Brasileira de Neurocirurgia

  •   Rua da Quitanda 159 – 10º andar - Centro - CEP 20091-005 - Rio de Janeiro - RJ
  •   +55 21 2233.0323
  •    abnc@abnc.org.br

Sponsor

  • Hospital INC